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Archive for the 'DNA Repair' Category

DNA Repair- A Vital Function

Posted in DNA Repair on January 16th, 2008 by Bradford

The capacity to remedy damage to DNA is a very important biological function. Mechanisms involved in the repair of DNA are found in all forms of life. How important is it? Is it neccessary to sustain life as we know it? My views are known at this site but am I alone in viewing DNA repair as a critically important function? Not if the views of many researchers are relevant. There are many papers touting the importance of DNA repair. Here are just some of the samples:

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A Genomic Balancing Act

Posted in DNA Repair, Evolution, Front-loading on February 18th, 2007 by Bradford

An article by Professor Steve Jones, View From the lab: mutations suggests reasons for the utility of a front loading paradigm. Current approaches take note of an existing balance between the potential for change and the need to maintain genomic function by preserving stability.

Mutations are essential to an evolutionary process. If there are none, change is not possible. While too many leads to the demise of an organism, or a species, a balance allows for adapative changes. Mutations are kept in check by multiple DNA repair mechanisms tageting different types of damage. Jones describes the repair processes:

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