Unless we are now living in a simulation, our descendants will almost certainly never run an ancestor-simulation.
In evolutionary informatics, two paramaters are needed for evolutionary algorithms. Heritability and Selection.
Heritability implies the following:
1) "Parents" give rise to "offspring".
2) Traits from "parents" are passed on to "offspring".
3) Each "offspring" from a "parent" signifies a new generation.
4) Variation between generations may or may not occur.
Selection implies that certain traits that are not on a fitness landscape will not be selected.
Let's look at Autodock as an example and how it relates to evolutionary informatics.