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Eukaryotic cells are dynamically ordered

by MikeGene

From here:

It has been a plausible and long-standing hypothesis that genomic regulatory networks of real cells operate in the ordered regime or at the border between order and chaos. This hypothesis is indirectly supported by the robustness and stability observed in the phenotypic traits of living organisms under genetic perturbations. However, there has been no systematic study to determine whether the gene-expression patterns of real cells are compatible with the dynamically ordered regimes predicted by theoretical models. Using the Boolean approach, here we show what we believe to be the first direct evidence that the underlying genetic network of HeLa cells appears to operate either in the ordered regime or at the border between order and chaos but does not appear to be chaotic.

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This entry was posted on Sunday, February 4th, 2007 at 11:05 am and is filed under Biology, Cell. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site. The trackback link is: http://telicthoughts.com/eukaryotic-cells-are-dynamically-ordered/trackback/

One Response to “Eukaryotic cells are dynamically ordered”

  1. Bradford Says:
    February 4th, 2007 at 6:35 pm

    It has been a plausible and long-standing hypothesis that genomic regulatory networks of real cells operate in the ordered regime or at the border between order and chaos.

    Stuart Kauffman developed random Boolean networks (RBNs) to model genetic regulatory networks. RBNs assume random generation of function to support the contention that living organisms are derived from random elements rather than elements that are precisely programmed. There was bias in the choice of models. Not surprisingly evolutionary dynamics would take place at the edge or border between order and chaos which would be the expected outcome for studies attempting to locate the zone in which lies the capacity to evolve. The logical inference is that the border was selected early on to make possible subsequent evolution. The question begged is how and in answering that question lies support for or evidence against ID. Whether the approach is one of organic chemistry, the generation of information or a mathematical model, the nexus of the dispute involving ID comes back to an origins issue. It is here that life could be front loaded for subsequent adaptation possibilites and resultant diversity. Models intending to exclude a telic inference at the outset have failed to explain origins issues. It's time that changed.

  2. Comment by Bradford — February 4, 2007 @ 6:35 pm

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