From here:

Scientists have shown in literally thousands of studies that the p53 gene deserves its reputation as "the guardian of the genome." It calls to action an army of other genes in the setting of varied cell stresses, permitting repair of damaged DNA or promoting cell death when the cell damage is too great. A key net effect of p53's action is to prevent development of cancerous cells.

Now, University of Michigan Medical School scientists provide the most thorough evidence yet that p53 also regulates a trio of genes from the realm of so-called "junk" genes "” the roughly 97 percent of a cell's genetic material whose function is only beginning to be understood.

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