This year's Nobel Prize for chemistry went to a pair of US scientists who worked on G-protein coupled receptors, or GPCRs. GPCRs are intracellular receptors used in sight, smell, brain regulation, immune system regulation, blood pressure, heart rate, digestion, homeostasis and many other functions. Here's a short video explaining the signaling mechanism.
Biologist and atheist activist Jerry Coyne's reaction to the awesome complexity of the signaling mechanism was to proclaim:
"The amazing complexity of the G-protein coupled cascade – which no designer would ever build – shows the truth of Jacob’s aphorism that evolution doesn’t design, it ‘tinkers’."
I agree that evolution has tinkered with GPCRs over the years, but I'd like to know why Coyne thinks that no designer would ever build a GPCR given it's incredible effectiveness, utility, modularity, ubiquity, and flexibility. I'd also like to know if Coyne is aware that GPCRs have existed since the very beginnings of multicellularity.
Seems to me to be an extremely ingenious design strategy to include GPCRs in the first unicellular organisms – that is, if a designer wanted to insure the appearance of multicellularity, plants, animals, bodies, noses, eyes, hearts, and minds.