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	<title>Comments on: The Unfolding of RecA</title>
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	<link>http://telicthoughts.com/the-unfolding-of-reca/</link>
	<description>An independent blog about intelligent design</description>
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		<title>By: MikeGene</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-137132</link>
		<dc:creator>MikeGene</dc:creator>
		<pubDate>Sat, 25 Aug 2007 13:56:58 +0000</pubDate>
		<guid isPermaLink="false">http://telicthoughts.com/the-unfolding-of-reca/#comment-137132</guid>
		<description>Hi Doug,

One more thing.  You asked, &quot;Is the removal of Rad51B, Rad51C, Rad51D, DMC1, XRCC2, or XRCC3 as lethal as the removal of both copies of Rad51 from a mammal?&quot;  Notice that the telic hypothesis I raised has led you to raise a question that could easily be turned into a testable hypothesis.  In fact, since I started speculating along these lines, both TP and Nick came up with their own testable hypotheses that would address some point along the way.</description>
		<content:encoded><![CDATA[<p>Hi Doug,</p>
<p>One more thing.  You asked, &#034;Is the removal of Rad51B, Rad51C, Rad51D, DMC1, XRCC2, or XRCC3 as lethal as the removal of both copies of Rad51 from a mammal?&#034;  Notice that the telic hypothesis I raised has led you to raise a question that could easily be turned into a testable hypothesis.  In fact, since I started speculating along these lines, both TP and Nick came up with their own testable hypotheses that would address some point along the way.</p>
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	<item>
		<title>By: MikeGene</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-136901</link>
		<dc:creator>MikeGene</dc:creator>
		<pubDate>Fri, 24 Aug 2007 21:32:44 +0000</pubDate>
		<guid isPermaLink="false">http://telicthoughts.com/the-unfolding-of-reca/#comment-136901</guid>
		<description>Hi Doug,

Since Nick answered your question, let me add a couple more things.  The seven versions are not always crucial.  Baker&#039;s yeast, a stream-lined unicellular fungus, only has four versions.  And fruit flies and mosquitoes are missing at least one of them.</description>
		<content:encoded><![CDATA[<p>Hi Doug,</p>
<p>Since Nick answered your question, let me add a couple more things.  The seven versions are not always crucial.  Baker&#039;s yeast, a stream-lined unicellular fungus, only has four versions.  And fruit flies and mosquitoes are missing at least one of them.</p>
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	<item>
		<title>By: MikeGene</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-136900</link>
		<dc:creator>MikeGene</dc:creator>
		<pubDate>Fri, 24 Aug 2007 21:29:26 +0000</pubDate>
		<guid isPermaLink="false">http://telicthoughts.com/the-unfolding-of-reca/#comment-136900</guid>
		<description>Hi Nick,

Butt in any time you want.  I think your long answer truly demonstrates what is great about the scientific community.  You actually took a little of your time to help others learns how to gather information on their own.  That was actually quite kind.</description>
		<content:encoded><![CDATA[<p>Hi Nick,</p>
<p>Butt in any time you want.  I think your long answer truly demonstrates what is great about the scientific community.  You actually took a little of your time to help others learns how to gather information on their own.  That was actually quite kind.</p>
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	<item>
		<title>By: Doug</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-136896</link>
		<dc:creator>Doug</dc:creator>
		<pubDate>Fri, 24 Aug 2007 21:26:01 +0000</pubDate>
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		<description>Greatly appreciated, Nick!</description>
		<content:encoded><![CDATA[<p>Greatly appreciated, Nick!</p>
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	<item>
		<title>By: Nick</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-136866</link>
		<dc:creator>Nick</dc:creator>
		<pubDate>Fri, 24 Aug 2007 19:40:11 +0000</pubDate>
		<guid isPermaLink="false">http://telicthoughts.com/the-unfolding-of-reca/#comment-136866</guid>
		<description>Hi Doug,

(Hopefully Mike won&#039;t mind me butting in...)

Short answer:  yes, for many of those genes, complete loss is embryonic lethal.

Long answer:
FYI,  you can find that info for those or any other genes that catch your interest at the Mouse Genome Informatics database

http://www.informatics.jax.org 

Enter the gene name in the search box (select Gene symbols/names in the drop down menu).  You&#039;ll find that most of the Rad51-family genes have different symbols in the mouse genome, but a search with the old symbol that Mike used will pull them up.

Click on the gene symbol to go to the detailed page.  Scroll down to &quot;Phenotypes&quot;  If the gene has been knocked out, one or more alleles will be listed for &quot;targeted&quot;  Sometimes there&#039;ll be a brief summary of the phenotype on the main page.  If not, you can click through to details of phenotype.</description>
		<content:encoded><![CDATA[<p>Hi Doug,</p>
<p>(Hopefully Mike won&#039;t mind me butting in&#8230;)</p>
<p>Short answer:  yes, for many of those genes, complete loss is embryonic lethal.</p>
<p>Long answer:<br />
FYI,  you can find that info for those or any other genes that catch your interest at the Mouse Genome Informatics database</p>
<p><a href="http://www.informatics.jax.org" rel="nofollow">http://www.informatics.jax.org</a> </p>
<p>Enter the gene name in the search box (select Gene symbols/names in the drop down menu).  You&#039;ll find that most of the Rad51-family genes have different symbols in the mouse genome, but a search with the old symbol that Mike used will pull them up.</p>
<p>Click on the gene symbol to go to the detailed page.  Scroll down to &#034;Phenotypes&#034;  If the gene has been knocked out, one or more alleles will be listed for &#034;targeted&#034;  Sometimes there&#039;ll be a brief summary of the phenotype on the main page.  If not, you can click through to details of phenotype.</p>
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	<item>
		<title>By: Doug</title>
		<link>http://telicthoughts.com/the-unfolding-of-reca/comment-page-1/#comment-136841</link>
		<dc:creator>Doug</dc:creator>
		<pubDate>Fri, 24 Aug 2007 18:13:32 +0000</pubDate>
		<guid isPermaLink="false">http://telicthoughts.com/the-unfolding-of-reca/#comment-136841</guid>
		<description>Hi Mike,
Is the removal of Rad51B, Rad51C, Rad51D, DMC1, XRCC2, or XRCC3 as lethal as the removal of both copies of Rad51 from a mammal?  As was the case with your example of the removal of Rad51 from a mouse.</description>
		<content:encoded><![CDATA[<p>Hi Mike,<br />
Is the removal of Rad51B, Rad51C, Rad51D, DMC1, XRCC2, or XRCC3 as lethal as the removal of both copies of Rad51 from a mammal?  As was the case with your example of the removal of Rad51 from a mouse.</p>
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